Genomic imprinting: Mother maintains methylation marks
نویسندگان
چکیده
منابع مشابه
Genomic imprinting: Mother maintains methylation marks
A DNA methyltransferase has been identified that plays a role in maintaining the methylation status of imprinted genes. Interestingly, although expressed in the unfertilised egg, this enzyme functions only during one round of replication in the eight-cell embryo.
متن کاملCompetitive signal discrimination, methylation reprogramming and genomic imprinting.
Genomic imprinting (parent-of-origin-dependent gene regulation) is associated with intra-genomic evolutionary conflict over the optimal pattern of gene expression. Most theoretical models of imprinting focus on the conflict between the maternally and paternally derived alleles at an imprinted locus. Recently, however, more attention has been focused on multi-directional conflicts involving not ...
متن کاملGenomic imprinting and methylation: epigenetic canalization and conflict.
Imprinted genes have patterns of expression that depend on the parent of origin of their alleles. Establishment of imprinting at a locus requires that the two alleles be differentially marked in oogenesis and spermatogenesis, that these marks escape reprogramming after fertilization, and that they are reliably transmitted through development. Recent work on the mammalian DNA methyltransferases ...
متن کاملRetrotransposon Silencing by DNA Methylation Can Drive Mammalian Genomic Imprinting
Among mammals, only eutherians and marsupials are viviparous and have genomic imprinting that leads to parent-of-origin-specific differential gene expression. We used comparative analysis to investigate the origin of genomic imprinting in mammals. PEG10 (paternally expressed 10) is a retrotransposon-derived imprinted gene that has an essential role for the formation of the placenta of the mouse...
متن کاملGenomic Imprinting
BACKGROUND Genomic imprinting is the inheritance out of Mendelian borders. Many of inherited diseases and human development violates Mendelian law of inheritance, this way of inheriting is studied by epigenetics. AIM The aim of this review is to analyze current opinions and options regarding to this way of inheriting. RESULTS Epigenetics shows that gene expression undergoes changes more com...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2001
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(01)00311-6